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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of uveal melanoma (UM)
ncRNA name hsa-miR-34a
ncRNA Category miRNA
Disease name uveal melanoma (UM)
Species Homo sapiens
Tissues/Cell_line human UM cell lines M17, M21, M23 and SP6.5; human melanocyte cell line D78; human embryonic kidney cell line HEK293; human UM specimens
Methods Northern blot, MTS cell proliferation, transwell assay, luciferase reporter assay, immunofluorescence staining, Western blot
Expression pattern down-regulated
Functional description miR-34a acts as a tumor suppressor in uveal melanoma cell proliferation and migration through the downregulation of c-Met.
PubMed ID 19029026
Year 2009
Title MicroRNA-34a inhibits uveal melanoma cell proliferation and migration through downregulation of c-Met.
Drug-related ncRNA NO

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